Alpha-synuclein structure, functions, and interactions - PMC
WEBMay 9, 2016 — As a molecular biomarker for the detection of PD in its earlier stages, alpha-synuclein (α-syn), which is a key component of Lewy bodies, in which it is found in an aggregated and fibrillar form, has attracted considerable attention. Here, α-syn is …
α-Synuclein in Parkinson's Disease - PMC - National Center for ...
WEBα-Synuclein is a presynaptic neuronal protein that is linked genetically and neuropathologically to Parkinson's disease (PD). α-Synuclein may contribute to PD pathogenesis in a number of ways, but it is generally thought that its aberrant soluble oligomeric conformations, termed protofibrils, are the toxic species that mediate …
Alpha-synuclein - Wikipedia
WEBAlpha-synuclein is a neuronal protein that regulates synaptic vesicle trafficking and subsequent neurotransmitter release. [6][7] It is abundant in the brain, while smaller amounts are found in the heart, muscle and other tissues. In the brain, alpha-synuclein is found mainly in the axon terminals of presynaptic neurons. [5] .
Alpha-synuclein in Parkinson’s disease and other ... - Nature
WEBMar 1, 2023 — Alpha-synuclein aggregates perturb dopaminergic transmission and induce presynaptic and postsynaptic dysfunctions.
Physiology, Synuclein - StatPearls - NCBI Bookshelf
WEBFeb 6, 2023 — Alpha-synuclein is a presynaptic protein that assists in presynaptic vesicle transportation and endocytosis. When it becomes misfolded and aggregates, it becomes toxic to mitochondria and neurons. Increased cellular oxidative stress leads to increased alpha-synuclein aggregation.
Advances in understanding the function of alpha-synuclein
WEBSep 1, 2023 — In this review, we first describe the cellular and animal models developed over recent years to study the physiological and pathological roles of this protein, including transgenic techniques, use of viral vectors and intracerebral injections …
Alpha-synuclein: from secretion to dysfunction and death
WEBJul 19, 2012 — The aggregation, deposition, and dysfunction of alpha-synuclein (aSyn) are common events in neurodegenerative disorders known as synucleinopathies.
Alpha-synuclein structure and Parkinson’s disease – lessons and ...
WEBJul 22, 2019 — Alpha-synuclein (αS) is the major constituent of Lewy bodies and a pathogenic hallmark of all synucleinopathathies, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA).
Parkinson's test (a-Synuclein seed amplification assay)
WEBOct 13, 2023 — Overview. A new Parkinson's test can identify people with Parkinson's disease during the early stages or even before symptoms begin. The test is called an alpha-synuclein seed amplification assay. Parkinson's testing reveals if there are clumps of alpha-synuclein in spinal fluid.
A topographical atlas of α-synuclein dosage and cell type
WEBMar 19, 2024 — Parkinson’s disease (PD) and related dementias exist along a clinical and pathological continuum, sharing a common protein pathology. α-synuclein (αSyn) undergoes aggregation and is thought to...