Targeting glutamine metabolism as a therapeutic strategy for …
WEBApr 3, 2023 — Uptake of extracellular asparagine prevents the death of glioblastoma cells in response to glutamine depletion by blocking the apoptotic function of a glutamine-induced endoplasmic reticulum ...
Asparagine promotes cancer cell proliferation through use as …
WEBApr 29, 2016 — Here, the authors show that intracellular asparagine, a glutamine-derived metabolite, is critical to cancer cell growth and can compensate glutamine deficiency by acting as an amino acid...
Asparagine synthetase: Function, structure, and role in disease
WEBDec 8, 2017 — Asparagine synthetase (ASNS) converts aspartate and glutamine to asparagine and glutamate in an ATP-dependent reaction. ASNS is present in most, if not all, mammalian organs, but varies widely in basal expression.
Asparagine: A Metabolite to Be Targeted in Cancers
WEBJun 19, 2021 — When environmental glutamine levels decline, asparagine can protect tumor cells from apoptosis or even support de novo glutamine biosynthesis in a context-dependent manner.
Asparagine, a critical limiting metabolite during glutamine …
WEBApr 11, 2018 — We found that asparagine plays a critical role in supporting protein synthesis during glutamine starvation, highlighting a possible approach to optimize the therapeutic efficacy of targeting glutamine metabolism in cancer.
Asparagine and Glutamine: Co-conspirators Fueling Metastasis
WEBMay 1, 2018 — The intricate relationship of asparagine and glutamine in fueling tumor cell survival, growth, and metastasis highlights metabolic adaption as an emerging hallmark of tumor development and metastatic progression.
Glutamine reliance in cell metabolism - Nature
WEBSep 17, 2020 — Glutamine enters through several plasma membrane glutamine transporters and is then utilized in the cytosol in processes such as the biosynthesis of nucleotides, asparagine, and UDP-GlcNAc.
Metabolism of asparagine in the physiological state and cancer
WEBMar 6, 2024 — Two enzymes are involved in asparagine metabolism: asparagine synthase (ASNS), which catalyses glutamine- or ammonia-dependent asparagine synthesis from aspartate, and asparaginase (ASNase), which hydrolyses asparagine to aspartate.
Asparagine Plays a Critical Role in Regulating Cellular Adaptation …
WEBOct 23, 2014 — Sustained levels of asparagine suppress apoptosis and promote cellular adaptation to depletion of glutamine and other nonessential amino acids, while intracellular depletion of asparagine induces apoptosis even in the face of an abundant supply of glutamine and other nonessential amino acids.
Role of glutamine and interlinked asparagine metabolism in vessel ...
WEBAug 15, 2017 — Asparagine further proved crucial in glutamine-deprived ECs to restore protein synthesis, suppress ER stress, and reactivate mTOR signaling. These findings reveal a novel link between endothelial glutamine …