Caspase-1: the inflammasome and beyond - PubMed
WEBCaspase-1 plays a fundamental role in innate immunity and in several important inflammatory diseases as the protease activates the pro-inflammatory cytokines proIL-1β and proIL-18. Caspase-1 itself is activated in different inflammasome complexes, which assemble in response to a variety of exogenous ….
Role of Caspase-1 in the Pathogenesis of Inflammatory …
WEBOct 20, 2020 · Caspase-1 is the first and extensively studied inflammatory caspase that is activated through inflammasome assembly. Inflammasome is a cytosolic formation of multiprotein complex that aimed to start inflammatory response against infections or …
Caspase 1 - an overview | ScienceDirect Topics
WEBCaspase-1 is a protein that plays a crucial role in the immune system. It is activated through the formation of an initiation complex called the inflammasome, resulting in the removal of certain peptide sequences and the production of two subunits. The active form of caspase-1 is a homodimer consisting of two p20 and two p10 subunits.
Caspases in cell death, inflammation and disease - PMC
WEBJun 6, 2019 · This caspase-1-regulated cell death mode frequently coincides with the secretion of IL-1β and IL-18, and the release of DAMPs (Vande Walle and Lamkanfi, 2016). In addition to caspase-1, the inflammatory caspase subfamily in humans consists of caspases 4 and 5 (Figure 1).
Inflammasome activation and regulation: toward a better understanding ...
WEBJun 9, 2020 · Both canonical inflammasome signaling engaging caspase-1 and noncanonical inflammasome activation recruiting caspase-4, caspase-5 (in humans), and caspase-11 (in mice) elicit an inflammatory...
Caspase-1: an integral regulator of innate immunity - PubMed
WEBCaspase-1 is a unique cysteine protease playing central roles in innate immunity. Pathogens, stress, and damage signals induce activation of caspase-1, typically mediated by proximity-induced autoproteolysis in multimeric protein complexes called the …
Caspases and their substrates | Cell Death & Differentiation - Nature
WEBMay 12, 2017 · Within this group, caspase-1 is the enzyme that has been best characterized and well known for processing of IL-1β involved in inflammation. Group II is formed by the apoptotic effector...
Caspase-1: an integral regulator of innate immunity
WEBJun 10, 2015 · Caspase-1 is a unique cysteine protease playing central roles in innate immunity. Pathogens, stress, and damage signals induce activation of caspase-1, typically mediated by proximity-induced autoproteolysis in multimeric protein complexes called the …
Caspase-1: is IL-1 just the tip of the ICEberg - Nature
WEBJul 5, 2012 · Caspase-1, formerly known as interleukin (IL)-1-converting enzyme is best established as the protease responsible for the processing of the key pro-inflammatory cytokine IL-1β from an inactive...
The protease caspase-1: Activation pathways and functions
WEBJul 12, 2024 · Caspase-1 is one of the main mediators of inflammatory caspases and has become a correspondent with inflammation and cell death. In cell death, caspase-1 was originally found to cause apoptosis in fibroblasts.
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