Targeting CDK1 in cancer: mechanisms and implications
WEBJun 13, 2023 · Oncogenic action of RNA binding motif protein 7 (RBM7) and histone deacetylase 6 (HDAC3) controls cell progression by stabilizing CDK1 mRNA and protein levels, respectively.
Premature activation of Cdk1 leads to mitotic events in S phase …
WEBSep 6, 2018 · On the other hand, Cdk1 AF MEFs exhibited premature and elevated phosphorylation of histone H3 on S10 as indicated by western blot (Fig. 3a) and FACS (Fig. 3d) at 16 h after release.
Cyclin-dependent kinase 1 - Wikipedia
WEBCyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine protein kinase, and is a key player in cell cycle regulation. [5]
CDK1 plays an important role in the maintenance of pluripotency …
WEBNov 6, 2014 · Given the improper maintenance of G2/M checkpoint in the CDK1 siRNA group, we went on to investigate mitotic progression using the mitosis-specific marker, phospho-Histone 3 (Ser10).
Histone H1 and cdk1 kinase activities in early embryos of four …
WEBIn all mouse strains, the histone H1 kinase activity remained low during the G2 arrest, while it showed values comparable to that of control embryos during mitosis. X-irradiation is known to induce a change in the phosphorylation …
Cdk1 Controls Global Epigenetic Landscape in Embryonic Stem Cells
WEBMay 5, 2020 · Cdk1 phosphorylates many proteins involved in epigenetic regulation, including writers and erasers of all major histone marks. Consistent with these findings, inhibition of Cdk1 altered histone-modification status of ES cells.
Cell Cycle-Dependent Transcription: The Cyclin Dependent Kinase Cdk1 …
WEBJan 24, 2022 · The cyclin-dependent kinase Cdk1 is best known for its function as master regulator of the cell cycle. It phosphorylates several key proteins to control progression through the different phases of the cell cycle.
Cyclin E/CDK2 and feedback from soluble histone protein regulate …
WEBHistone transcription is triggered by cyclin E-CDK2’s phosphorylation of NPAT. •. HLB formation and activation of histone transcription are decouplable. •. DNA replication regulates histone mRNA degradation via soluble histone levels. Summary.
Polo‐like kinase‐1 triggers histone phosphorylation by Haspin in ...
WEBHere we show that Plk1 binds to Haspin in a Cdk1‐phosphorylation‐dependent manner. Reducing Plk1 activity decreases the phosphorylation of Haspin and inhibits H3T3ph, particularly in prophase, suggesting that Plk1 is required …
Polo-like kinase-1 triggers histone phosphorylation by Haspin …
WEBHere we show that Plk1 binds to Haspin in a Cdk1-phosphorylation-dependent manner. Reducing Plk1 activity decreases the phosphorylation of Haspin and inhibits H3T3ph, particularly in prophase, suggesting that Plk1 is required …