Viral detection by electron microscopy: past, present and future
WEBJan 9, 2012 · The first use of TEM in clinical virology concerned the differential diagnosis of smallpox (caused by the variola virus of the poxvirus family) and chicken pox (caused by the varicella‐zoster virus of the herpes family) using fluid from the vesicles on the patients' skin (Nagler and Rake, 1948).
Poxvirus under the eyes of electron microscope - PMC
WEBNov 14, 2022 · More recently, development of cryo-electron microscopy (cryo-EM) and electron tomography (ET) have facilitated molecular understanding of poxviruses as well as the structural insights into replicative machineries of poxviruses.
Modern Uses of Electron Microscopy for Detection of Viruses
WEBEM is instrumental in the detection of poxviruses in clinical samples and can be used to differentiate variola virus, the causative agent of smallpox, from varicella-zoster virus, a herpesvirus that is the causative agent of chicken pox and shingles.
Near-atomic cryo-electron microscopy structures of varicella-zoster ...
WEBSep 7, 2020 · Here we report the cryo-electron microscopy structures of purified VZV A-capsid and C-capsid, as well as of the DNA-containing capsid inside the virion.
Poxvirus under the eyes of electron microscope - PubMed
WEBNov 14, 2022 · In this review, we describe some of the major findings in poxvirus morphogenesis and the contributions of continuously advancing electron microscopy techniques. Keywords: Poxvirus; Transmission electron microscopy; Virus morphogenesis.
Cryo-EM study yields new clues to chicken pox infection
WEBAug 18, 2020 · Now researchers studying one herpesvirus, the varicella zoster virus (VZV) that causes chicken pox, may have found an important clue: A key protein the virus uses to initiate infection does not...
Cryo-EM study yields new clues to chicken pox infection - Phys.org
WEBAug 19, 2020 · The results were made possible by high-resolution cryo-electron microscopy (cryo-EM), which showed that the immune system can prevent infection by attacking a spot on the protein in an...
Chickenpox - SpringerLink
WEBJan 5, 2021 · Series of electron micrographs showing the uptake of a virus by a human cell and the subsequent formation of a virus-containing vacuole inside the cell. ( a ) The cell membrane begins to form an indentation when the virus binds to it.
Cryo-EM study yields new clues to chicken pox infection
WEBAug 18, 2020 · Now researchers studying one herpesvirus, the varicella zoster virus (VZV) that causes chicken pox, may have found an important clue: A key protein the virus uses to initiate infection does not operate as previously thought, researchers at Stanford University and the Department of Energy’s SLAC National Accelerator Laboratory report August 18 ...
Near-atomic cryo-electron microscopy structures of varicella
WEBVaricella-zoster virus (VZV) is a medically important human herpesvirus that causes chickenpox and shingles, but its cell-associated nature has hindered structure studies. Here we report the cryo-electron microscopy structures of purified VZV A-capsid and C-capsid, as well as of the DNA-containing c ….