Structural insight into substrate preference for TET-mediated
WEBOct 28, 2015 — Here Yanhui Xu and colleagues show that human TET proteins are evolutionarily tuned to be less reactive towards 5hmC than to 5fC and 5caC, facilitating its generation as a potentially stable...
Structural insight into substrate preference for TET-mediated ... - PubMed
WEBNov 5, 2015 — Our studies demonstrate that the substrate preference of TET2 results from the intrinsic value of its substrates at their 5mC derivative groups and suggest that 5hmC is relatively stable and less prone to further oxidation by TET proteins.
TET2-Mediated mRNA and DNA Oxidation in Leukemia Homing …
WEBNov 15, 2022 — Emerging evidence strongly indicates that dysregulation of chemical modifications in DNA or RNA leads to hematopoietic malignancies, including acute myeloid leukemia (AML). Tet methycytosine dioxygenases 2 (TET2) mutations have been characterized in 15-20% AML and its deficiency promotes leukemogenesis and leukemia stem cell (LSC) self-renewal.
TET-mediated DNA demethylation controls gastrulation by
WEBOct 19, 2016 — Here, Guo-Liang Xu and colleagues show that inactivation of all three Tet genes in mice leads to gastrulation phenotypes similar to those in embryos with increased Nodal signalling.
Ascorbic acid improves parthenogenetic embryo development through TET ...
WEBJan 11, 2019 — Ascorbic acid (Vc, Vitamin C) stimulates the expression of TET proteins, whereas DMOG (dimethyloxallyl glycine) inhibits TET … The TET (Ten-Eleven Translocation) proteins catalyze the oxidation of 5mC (5-methylcytosine) to 5hmC (5-hydroxymethylcytosine) and play crucial roles in embryonic development.
TET enzymes regulate skeletal development through increasing …
WEBAug 11, 2022 — TET-mediated DNA demethylation controls the proper differentiation of embryonic stem cells and TET members display functional redundancy during early gastrulation.
Ascorbic Acid Enhances Tet-Mediated 5-Methylcytosine Oxidation …
WEBJun 14, 2013 — Here, we demonstrate that a vital nutrient ascorbic acid (AA), or vitamin C (Vc), can directly enhance the catalytic activity of Tet dioxygenases for the oxidation of 5-methylcytosine (5mC).
A vitamin-C-derived DNA modification catalysed by an algal TET ...
WEBOur study thus identifies a eukaryotic DNA base modification that is catalysed by a divergent TET homologue and unexpectedly derived from vitamin C, and describes its role as a potential epigenetic mark that may counteract DNA …
Tet Enzymes, Variants, and Differential Effects on Function
WEBMar 5, 2018 — Discovery of the ten-eleven translocation 1 (TET) methylcytosine dioxygenase family of enzymes, nearly 10 years ago, heralded a major breakthrough in understanding the epigenetic modifications of DNA.
Dong Xu - Merlin Solar Technologies (a spin-off of GTAT) - LinkedIn
WEBOthers named Dong Xu in United States. Dong Xu Columbia, MO. Dong Xu New York City Metropolitan Area. Dong Xu Chicago, IL. Dong Xu Belle Mead, NJ. 79 others named Dong Xu in United States are on ...
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- Location: Merlin Solar Technologies (a spin-off of GTAT)