MICOS assembly controls mitochondrial inner membrane remodeling …
WEBJun 22, 2020 · Aberrant cristae in MICOS‐deficient mitochondria re‐attach to the mitochondrial inner membrane and convert into lamellar cristae upon re‐expression of MICOS. Interplay between MICOS subcomplexes, OPA1, and the F 1 F o ‐ATP synthase controls size and distribution of MICOS assemblies.
Mitochondria and MICOS - function and modeling - PubMed
WEBFeb 19, 2024 · An extensive review is presented on mitochondrial structure and function, mitochondrial proteins, the outer and inner membranes, cristae, the role of F 1 F O -ATP synthase, the mitochondrial contact site and cristae organizing system (MICOS), the sorting and assembly machinery morphology and function, and phospholipids, in …
The MICOS complex, a structural element of mitochondria with ... - PubMed
WEBMay 26, 2020 · Here we will review the current knowledge of the MICOS complex, one of the major structural elements of mitochondria. MICOS is a multi-subunit complex present in the inner mitochondrial membrane.
Regulated membrane remodeling by Mic60 controls formation of …
WEBMay 31, 2017 · The mitochondrial contact site and cristae organizing system (MICOS) is crucial for the formation of crista junctions and mitochondrial inner membrane architecture. MICOS contains two...
Mic60/Mitofilin determines MICOS assembly essential for
WEBAug 7, 2015 · The MICOS complex (mitochondrial contact site and cristae organizing system) is essential for mitochondrial inner membrane organization and mitochondrial membrane contacts, however, the...
MICOS and the mitochondrial inner membrane morphology
WEBMICOS, the F 1 F O -ATP synthase, OPA1 and inner membrane phospholipids such as cardiolipin and phosphatidylethanolamine interact with each other to organize the inner membrane ultra-structure and remodel cristae in response to the cell's demands.
MICOS and the mitochondrial inner membrane morphology
WEBApr 10, 2021 · This review discusses emerging evidence of a direct relationship between protein- and lipid-dependent regulation of the inner mitochondrial membrane morphology and diseases such as fatal encephalopathy, Leigh …
MICOS coordinates with respiratory complexes and lipids to …
WEBApr 28, 2015 · A large inner membrane complex of proteins known as MICOS is important for organizing the inner membrane into folds, although exactly how it does so is not fully understood. MICOS consists of at least six different proteins, most of which are found across yeast and animal species.
The MICOS complex of human mitochondria | Cell and Tissue …
WEBJun 1, 2016 · The MICOS complex in human mitochondria exhibits specificities and greater complexity in comparison to the yeast system. Many subunits of this complex have been previously described, but several others and their function remain to be explored.
Mic19 depletion impairs endoplasmic reticulum-mitochondrial …
WEBJan 2, 2024 · Here, we show that Mic19, a key subunit of MICOS (mitochondrial contact site and cristae organizing system) complex, regulates ER-mitochondria contacts by the EMC2-SLC25A46-Mic19 axis.
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