miRNA Mimics & Inhibitors | Thermo Fisher Scientific - US
WEBmirVana miRNA inhibitors are chemically modified, single-stranded oligonucleotides with patented secondary structure designed to specifically bind to and inhibit endogenous miRNAs, resulting in up-regulation of target mRNA translation.
MicroRNA therapeutics: towards a new era for the …
WEBFeb 17, 2017 · MicroRNA (miRNA)-based therapeutics can be divided into miRNA mimics and inhibitors of miRNAs (also known as antimiRs). miRNA mimics are synthetic double-stranded small RNA molecules that match...
Therapeutic advances of miRNAs: A preclinical and clinical update
WEBFeb 1, 2021 · Recent clinical trial data indicate that the anti-miR compounds, specific inhibitors for miRNAs, are the potential and a new class of drugs [18].
MicroRNA: trends in clinical trials of cancer diagnosis and therapy ...
WEBJul 10, 2023 · The researchers discuss the development of drug mimics or inhibitors of specific microRNAs that are now in or nearing human testing as potential anti-cancer therapeutics.
Anti-miRNA oligonucleotides: A comprehensive guide for design
WEBMar 23, 2018 · MiRNA-Masking Antisense Oligonucleotides technology (miR-Mask, also known as BlockmiR, target protectors or as target site blockers) relies on an inverted approach: instead of blocking the target miRNA, these molecules shield the mRNA which function is desirable to preserve.
MicroRNA Mimics or Inhibitors as Antiviral Therapeutic …
WEBFeb 27, 2021 · We can take advantage of their ability to modulate host–virus interactions through mediating RNA degradation or translational inhibition. Investigations into miRNA and SARS-CoV-2 interactions can reveal novel therapeutic approaches against this virus.
microRNA inhibitors: Natural and artificial sequestration of …
WEBOct 28, 2017 · Artificial miRNA inhibitors are RNA transcripts that are synthesized via chemical and genetic methods. Artificial miRNA inhibitors can be used in miRNA loss-of-function research and gene therapies for certain diseases. In this review, we summarize the recent advances in the two different types of miRNA inhibitors.
microRNA inhibitors: Natural and artificial sequestration of ... - PubMed
WEBOct 28, 2017 · Artificial miRNA inhibitors can be used in miRNA loss-of-function research and gene therapies for certain diseases. In this review, we summarize the recent advances in the two different types of miRNA inhibitors.
Emerging concepts of miRNA therapeutics: from cells to clinic
WEBMar 16, 2022 · The general aim of miRNA therapeutics is to modify and ideally reverse pathological miRNA expression changes. This includes the enhancement or reconstitution of endogenous miRNAs that act as pathological suppressors and the expressional reduction or functional blocking of miRNAs that act as pathological drivers.
Specificity and functionality of microRNA inhibitors - PMC
WEBApr 1, 2010 · Synthetic miRNA inhibitor designs incorporate the reverse complement of the mature miRNA (the target site) and are chemically modified to prevent RISC-induced cleavage, enhance binding affinity and provide resistance to nucleolytic degradation (for …