Targeted protein degradation: mechanisms, strategies and …
WEBApr 4, 2022 · Targeted protein degradation (TPD), via the proteasomal and lysosomal pathways, represent a novel tool to explore cellular pathways and a promising therapeutic approach. 29 The concept of TPD...
Protein Degradation - The Cell - NCBI Bookshelf - National …
WEBThe half-lives of proteins within cells vary widely, from minutes to several days, and differential rates of protein degradation are an important aspect of cell regulation. Many rapidly degraded proteins function as regulatory molecules, such as transcription factors.
Targeted protein degradation: from mechanisms to clinic
WEBApr 29, 2024 · This article reviews the current landscape of targeted protein degradation approaches and how they have parallels in biological processes.
Mechanisms of Protein Degradation - Thermo Fisher Scientific
WEBThe two major protein degradation pathways—the UPS and the lysosomal proteolysis pathway —regulate many cellular processes, including cell cycle, cell signaling, stress response, apoptosis, autophagy, protein expression, and DNA transcription.
Targeted Protein Degradation: Advances, Challenges, and …
WEBAug 21, 2023 · Targeted protein degradation necessitates a novel approach to small molecule drug discovery, shifting from static structures that function primarily via occupancy-driven pharmacology to conformational stabilization within a complex free energy landscape to achieve catalytic turnover.
Protein degradation on the global scale - Cell Press
WEBApr 21, 2022 · Protein degradation occurs through proteasomal, endosomal, and lysosomal pathways. Technological advancements have allowed for the determination of protein copy numbers and turnover rates on a global scale, which has provided an overview of trends and rules governing protein degradation.
Targeted Protein Degradation: Principles, Strategies, and …
WEBJul 30, 2023 · This review focuses on recent advances in targeted protein degradation techniques, summarizing the principles, advantages, and challenges. Moreover, the potential applications and future direction in biological science and …
Protein Degradation - an overview | ScienceDirect Topics
WEBProtein degradation in living cells is a highly selective process in which damaged or misfolded proteins are readily targeted for destruction. However, this process extends far beyond the removal of inactive proteins.
Targeted protein degradation: A promise for undruggable proteins
WEBMay 17, 2021 · targeted protein degradation. PROTACs. proteasome. ubiquitination. undruggable proteome. Introduction. The cell is a complex system with coordinated biological processes carried out by more than 20,000 individual proteins.
Targeted protein degradation as a powerful research tool in basic ...
WEBJun 15, 2020 · This paper shows the method of using chimeric macromolecular conjugates to target proteins for degradation by the lysosomal pathway.