Granulocyte colony-stimulating factor - Wikipedia
WEBThe natural human glycoprotein exists in two forms, a 174- and 177-amino-acid-long protein of molecular weight 19,600 grams per mole. The more-abundant and more-active 174-amino acid form has been used in the development of pharmaceutical products by recombinant DNA (rDNA) technology.
Effect of Recombinant Human Granulocyte Colony-Stimulating ... - PubMed
WEBJan 1, 2021 · Main outcomes and measures: The primary end point was the time from randomization to improvement of at least 1 point on a 7-category disease severity score. Results: Of 200 participants, 112 (56%) were men and the median (interquartile range [IQR]) age was 45 (40-55) years.
Effect of Recombinant Human Granulocyte Colony ... - JAMA …
WEBThe blue curve indicates the recombinant human granulocyte colony-stimulating factor (rhG-CSF) group, whereas the orange curve denotes the control group (usual care). The hazard ratio (HR) of achieving clinical improvement, along with the 95% CI and the P value, is also reported.
Biologic and molecular effects of granulocyte colony-stimulating factor ...
WEBFeb 15, 2008 · Recombinant human granulocyte colony-stimulating factor (rhG-CSF) is widely used in healthy donors for collection of peripheral blood progenitor cells (PBPCs) for allogeneic transplantation and granulocytes for transfusion.
Efficacy and safety of PEG-rhG-CSF versus rhG-CSF in preventing ...
WEBJul 26, 2023 · To compare the clinical value of recombinant human granulocyte colony-stimulating factor (rhG-CSF) and pegylated rhG-CSF (PEG-rhG-CSF) in early-stage breast cancer (EBC) patients receiving adjuvant chemotherapy, compare the efficacy of PEG-rhG-CSF with different dose and explore the timing of rhG-CSF rescue treatment.
Pegylated recombinant human granulocyte colony‐stimulating …
WEBFeb 5, 2020 · Pegylated recombinant human granulocyte colony‐stimulating factor (PEG‐rhG‐CSF) is widely used for primary or secondary prophylaxis of febrile neutropenia (FN) in chemotherapy. However, whether PEG‐rhG‐CSF influences immune cells, such as lymphocytes, remains unclear.
Pharmacokinetics and safety of pegylated recombinant human
WEBJan 28, 2021 · This open-label, phase I study evaluated the pharmacokinetics and safety of pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) for the treatment of chemotherapy-induced neutropenia in children with acute leukaemia.
Effects of Recombinant Human Granulocyte Colony-Stimulating …
WEBIn an attempt to stimulate neutrophil production and thereby reduce the morbidity and mortality associated with this disease, we administered recombinant human granulocyte colony-stimulating...
Efficacy and safety of 3 mg pegylated recombinant human …
WEBNov 17, 2021 · NCCN guidelines recommend a dose of 100 μg/kg or a fixed dose of 6 mg pegylated recombinant human granulocyte colony‐stimulating factor (PEG rhG‐CSF) for chemotherapy‐induced neutropenia.
A novel PEGylated form of granulocyte colony-stimulating factor ...
WEBJul 24, 2023 · Mobilization with recombinant human granulocyte colony stimulating factor (rhG-CSF) has become the standard procedure for peripheral blood hematopoietic stem cell transplantation.