He has homed in on specific enzyme classes: proteases, hydrolases, histone deacetylases and others ... forms of the cyclin-dependent kinase (Cdk1) 8. The researchers identified 547 phosphorylation ...

The spatiotemporal specific localization of MELK depends on the interaction between its Threonine-Proline (TP) rich domain and kinase associated 1 (KA1) domain, which is regulated by CDK1 kinase and ...

The beads are called nucleosomes. Each nucleosome is made of DNA wrapped around eight histone proteins that function like a spool and are called a histone octamer. Each histone octamer is composed ...

Reversible histone glycation is associated with disease-related changes ... From Ubiquitin-Proteasomal Degradation to CDK1 Inactivation: Requirements for the First Polar Body Extrusion in Mouse ...

Replication-dependent (RD) core histone mRNA produced during S-phase is the only known metazoan protein-coding mRNA presenting a 3' stem-loop instead of the otherwise universal polyA tail. A metallo β ...

Why deprotected cohesin is not removed by Wapl remains enigmatic. By reconstituting Wapl-dependent cohesin removal from chromatin in vitro, we discovered a requirement for Nek2a and Cdk1/2-cyclin A2.

Similarly, silencing of LMTK3 led to an increase in phospho-histone H3 (Ser10) levels ... downstream proteins involved in cell cycle regulation and microtubule stability (CDK1 and phospho-βIII tubulin ...

Identification of potent COVID-19 main protease inhibitors by loading of favipiravir on Mg12O12 and Zn12O12 nanoclusters: an in silico strategy for COVID-19 treatment.

Retraction Note: M2 macrophage-derived extracellular vesicles promote gastric cancer progression via a microRNA-130b-3p/MLL3/GRHL2 signaling cascade. Retraction Note ...