The breakthrough research was conducted by scientists at the Indian Association for the Cultivation of Science (IACS), ...

In a promising development for cancer treatment, researchers have pinpointed a new target by activating a DNA repair enzyme ...

Scientists have identified a promising new target for cancer treatment by activating a DNA repair enzyme called TDP1, ...

2b). Phosphorylation of CKI is initiated by Cdk–cyclin complexes (Cdk1–Cln1,2 in budding yeast, Cdk1–Cig1 in fission yeast) that are not inhibited by the CKI. Consistent with this model ...

Researchers discovered the molecular mechanism regulating the replenishment of centromeric protein A (CENP-A) at the ...

GlobalData’s report assesses the drugs in the Cyclin Dependent Kinase 7 pipeline by therapy areas, indications, stages, MoA, RoA, molecule type and the key players in the development pipeline.

A cascade of events"We closed a gap in our knowledge that was open for 10 years," says Duccio Conti, a postdoc in the Musacchio group and first author ...

Exogenous expression of aurora A led to an accumulation of ubiquitylated MYCN, indicating that stabilization is effected at a post-ubiquitylation step. However, transfection of ubiquitin in which ...

They assessed mitochondrial adenosine triphosphate (ATP) generation capability by analyzing oxidative phosphorylation ... and ...

CDK7 is a key player in the activation of other cyclin-dependent kinases (CDKs), particularly CDK1, CDK2, CDK4, and CDK6, which are crucial for cell cycle progression. Moreover, CDK7 is involved in ...