(D) Based on the results of cyclin and CDK-knockout studies, scientists have constructed a new threshold model of cell cycle control. Accordingly, either CDK1 or CDK2 bound to cyclin A is ...

Researchers developed novel genetic tools to trace, ablate, and manipulate p16^Ink4a+^ senescent cells, revealing their ...

However, activating phosphorylation of Cdk by CAK appears to be an exception to this trend. In fact, CAK activity remains high throughout the cell cycle and is not regulated by any known cell-cycle ...

Today, attention is turning to understand how non-proliferating cells, cells that have exited the cell cycle, retain their capacity to re-enter when necessary. In the past, this labs study of G1 ...

By Pooja Toshniwal Paharia Breakthrough research sheds light on the genetic mutation behind aggressive prostate cancer. Study ...

Cell cycle events are controlled tightly by several kinase families including CDKs, Plks, and Aurora kinases. What is interesting about these kinases is that they don't always act alone.

GlobalData’s report assesses the drugs in the Cyclin Dependent Kinase 7 pipeline by therapy areas, indications, stages, MoA, RoA, molecule type and the key players in the development pipeline.

The breakthrough research was conducted by scientists at the Indian Association for the Cultivation of Science (IACS), ...

The cell cycle is regulated by a number of important protein families which are common targets for mutational inactivation or overexpression in human tumours. The cyclin D and E families and their ...

In this issue, Papismadov et al (2024) report that p21 (CDKN1A), known to activate the senescence growth arrest, also ...

In a promising development for cancer treatment, researchers have pinpointed a new target by activating a DNA repair enzyme ...