Chen led work that resulted in the discovery of a critical enzyme — cyclic GMP-AMP synthase (cGAS) — that acts like a fire ...

One of its central components is the enzyme cyclic GMP-AMP synthase (cGAS), which acts as a sentinel, detecting foreign DNA and initiating an immune response. However, the immune system requires ...

Eiki Takimoto; Hunter C Champion; Manxiang Li; Diego Belardi; Shuxun Ren; E Rene Rodriguez; Djahida Bedja; Kathleen L Gabrielson; Yibin Wang; David A Kass ...

Ferid Murad, 62 (University of Texas Medical School, Houston) discovered that the gas activates the cyclic GMP signal transduction pathway and that the vasodilator nitroglycerin ameliorates heart ...

Viagra works by increasing blood flow to the penis when the user is aroused, releasing a neurotransmitter into the smooth muscle cell of the arteries and creating a substance called cyclic GMP ...

Phosphodiesterase enzymes cleave the phosphodiester bonds in secondary intramolecular messengers like cyclic-AMP and cyclic-GMP, which are involved in many biological processes that include ...

“I was really surprised to get the news,” said Chen. “[This award] is really very special.” Chen’s discovery of cGAS, short for cyclic guanosine monophosphate-adenosine monophosphate synthase, in 2013 ...

We didn’t expect it to be an enzyme.” When the enzyme, called cyclic GMP-AMP synthase (cGAS), detects any type of DNA in the cell’s soupy interior — also known as the cytoplasm — it ...

This process begins when cGAS binds to cytoplasmic DNA and in response synthesizes cyclic GMP-AMP (cGAMP), which in turn activates STING (stimulator of interferon genes). STING then triggers an ...

TREX1 is an enzyme that degrades cytosolic DNA (a danger signal) and prevents it from binding to cyclic GMP–AMP synthase (cGAS) and activating the STING pathway. Mutations in TREX1 cause ...

A cardiac pathway of cyclic GMP-independent signaling of guanylyl cyclase A, the receptor for atrial natriuretic peptide. Proc Natl Acad Sci USA 108: 18500-5. * These authors contributed equally to ...