Histone acetylation is a dynamic process controlled by the antagonistic actions of two large families of enzymes — the histone acetyltransferases (HATs) and the histone deacetylases (HDACs).

Epigenetics, the study of changes in gene function that do not involve alterations to the DNA sequence, plays a pivotal role ...

which paralleled acetylation of K9 and K14, while transcriptionally inactive chromatin was associated with K9 methylation. While this study supports the existence of gene regulation by a histone ...

A research team, delving into the impact of excessive prenatal prednisone exposure (PPE) on fetal development, discovered ...

Research uncovers the critical role of carnitine transporters in maintaining fertility by regulating energy metabolism and ...

Study reveals widespread dysregulation of transposable elements (TEs) in aging human brains with Alzheimer's disease, using ...

The basic organizational unit of the genome is a nucleosome, which is a short segment of DNA wound around a complex of eight histone subunits. Each of these histones has a tail region which can be ...

The sequencing of the human genome at the turn of the 21st century was heralded as a monumental scientific achievement ...

Many donor molecules for histone PTMs are metabolites (e.g., acetyl-CoA is utilized for acetylation), which directly links cellular metabolism to the chromatin landscape. Yet the direct mechanisms and ...

Diffuse midline glioma (DMG) is a highly aggressive and fatal pediatric high-grade glioma that primarily affects critical ...

In fact, biological outcomes are often due to physical interactions between proteins that are so highly selective that seemingly minor chemical modifications (i.e. methylation, acetylation or ...