Study identifies compounds that extend longevity of Japanese morning glory flowers
The longevity of plant flowers is controlled by genetically programmed mechanisms. After a certain amount of time after ...
technologynetworks10d
Targeted Protein Degradation: A Promising Therapeutic Strategy for the Most Challenging Protein Targets
Targeted protein degradation (TPD) is getting a lot of attention as a promising modality to treat a variety of diseases from ...
AlphaGalileo11h
Identification of Compounds extending the longevity of Japanese morning glory flowers
The compounds Everlastin1 and Everlastin2, which inhibit the binding of the transcription factor EPHEMERAL1 (EPH1), a ...
News Medical on MSN23h
UNF professor secures NIH grant to investigate enzyme's role in muscle atrophy
A University of North Florida biology professor has been awarded a prestigious four-year National Institutes of Health (NIH) ...
Nature1y
Uniting the protein degradation generation
Things often seem either black or white within the targeted protein degradation (TPD) space. The biology behind degrading therapeutic targets that are difficult or dangerous to inhibit is well ...
Phys.org29d
Algorithm maps protein degradation patterns to improve infection diagnosis and treatment
The research team aimed to understand the degradation patterns of proteins to more quickly identify the bacteria involved and assess the risk of sepsis. The rise of antibiotic resistance has also ...
Knowridge8d
New drug could help treat tough cancers, study finds
Researchers at the University of Dundee’s Centre for Targeted Protein Degradation (CeTPD) and Boehringer Ingelheim have ...
C&EN10d
Degrader takes out many forms of KRas
Molecule sends 13 of the 17 most common forms of this cancer-related protein to the cell’s garbage-disposal system ...
icr.ac.uk11mon
Research at the Centre for Protein Degradation
The Centre for Protein Degradation was developed out of years of degraders research by scientists who explored targeted protein degradation (TPD) as a therapeutic modality. Our extensive structural ...
Kymera Therapeutics Presents Preclinical Data for KT-621, a Potent, Selective, First-In-Class, Oral STAT6 Degrader at the EADV Congress
KT-621 has the potential to provide dupilumab-like activity with an oral small molecule profile for TH2 driven allergic and atopic diseaseKT-621 ...
icr.ac.uk11mon
Meet the team at the Centre for Protein Degradation
The Centre for Protein Degradation also draws expertise from existing drug discovery teams within the ICR's Centre for Cancer Drug Discovery. Professor Zoran Rankovic, Director and Group Leader ...