Rapamycin is typically prescribed to organ transplant patients to suppress their immune systems. But many scientists and ...

Unfortunately, the evidence we have right now simply isn’t convincing. It’s possible that taking rapamycin could help with fertility, but we have no real idea if it does. Rapamycin has been a ...

Several analogs of rapamycin, or rapalogs, are also currently in various stages of clinical development, including temsirolimus (CCI-779), everolimus (RAD-001) and deforolimus (AP23573).

Rapamycin has been trending on social media, where biohackers such as Dr. Peter Attia and Bryan Johnson tout it as the “gold standard” for people seeking to live a longer, healthier life ...

Rapamycin has been called a potential miracle drug, capable of slowing the effects of aging - everything from greying hair to ...

Charles Sawyers and colleagues have conducted a small early-stage clinical study to assess target modulation by the small-molecule inhibitor rapamycin. Rapamycin is approved to treat renal cancer ...

Rapamycin is used by transplant patients to keep organs from being rejected. Now, researchers are excited about the potential use to stop the aging clock. An off-label use for a prescription drug ...

inhibitor (sirolimus or everolimus) that the patient was taking at the time of randomization was allowed but not required (see the Methods section in the Supplementary Appendix, available at NEJM ...

2010;67(24):2095-2106. Temsirolimus is primarily metabolized by the cytochrome P-450 (CYP) 3A4 isoenzyme to five major metabolites, with sirolimus being the principal active metabolite.

See Contraindications. QT prolongation with concomitant dofetilide, quinidine, pimozide, cisapride, methadone, disopyramide, dronedarone, ranolazine. Concomitant ...

Nursing mothers. Concomitant live vaccines: not recommended. Concomitant mTOR inhibitors (eg, sirolimus, everolimus) may increase risk of thrombotic microangiopathy. Concomitant mycophenolic acid ...

The STOPN trial is designed to determine whether the drug sirolimus slows down disease progression based on volumetric MRI measurements in children and adults with neurofibromatosis type 1 (NF1) and ...