She worked with a gene called STAT1, which stands for signal transducer and activator of transcription-1. Defects in STAT1 can present themselves in multiple ways. The lab she trained in discovered ...

Additionally, to investigate the cellular basis of STAT1 activation in RA ST. Methods: ST specimens from 12 patients with RA and 14 disease controls (patients with osteoarthritis and reactive ...

I have a few PCBs that have both BQ24650's stat1 and stat2 LEDs illuminated simultaneously. With no input voltage, neither of the LEDs is glowing. As I start ramping up input, the red LED starts to ...

Objectives: JAK-STAT inhibition is an attractive therapeutic possibility for SLE (3.). We assess STAT1 and STAT3 expression and phosphorylation at baseline and after IFN type I and II stimulation in B ...

Investigation of PHLPP1 function in macrophages reveals that it controls the magnitude and duration of inflammatory signaling by dephosphorylating the transcription factor STAT1 on Ser727 to inhibit ...

Initial results from a phase III clinical trial show that simvastatin does not slow down progression in secondary progressive ...

I get a fault output on STAT1 & STAT2 when the voltage is under 12V, when I programmed it via hardware to have a minimum input of 9V. Here is a link to my design ...

1 University of Cincinnati and the Centre for Autoimmune Genomics and Aetiology (CAGE), Cincinnati Children’s Hospital Medical Centre, Cincinnati, OH 2 US Department of Veterans Affairs Medical Centre ...

We provide evidence of a novel mechanism involving DDX5 that enables translation of transcription factor STAT1 mediating the IFN response. Design and results Molecular, pharmacological and biophysical ...

Therefore, maintaining proper JAK-STAT function is crucial for systemic immune homeostasis and well-being. Variations within JAK-STAT1/3/5-SOCS genes due to genetic changes can alter the function of ...

Summary and Introduction Clinical Application—Disease Entities Theoretical Framework for Therapy−The 'Steel Paradigm' Conclusion References Theoretical Framework for Therapy−The 'Steel ...

Moreover, we also found that LINC00113 could bind to DNMT1 to promote the methylation of promoter sequence of STAT1 and leading to the down-regulation of STAT1, which act as a tumour suppressor in ...