Tissue necrosis is a devastating complication for many human diseases and injuries. Unfortunately, our understanding of necrosis and how it impacts surrounding healthy tissue – an essential ...

Mechanistically, the cleavage of TDP-43 at Asp89 by HIV-1 relies on Vpu-mediated activation of Caspase 3, and pharmacological inhibition of Caspase 3 activity effectively suppressed the HIV-1-induced ...

(B) Representative images of S2 cells expressing caspase sensitive-QF2 probes by the Gal4/UAS system with FLP-mediated recombination. Scale bar: 20 µm. (C) Representative images of adult male brains ...

GlobalData’s report assesses the drugs in the Bcl 2 Like Protein 1 pipeline by therapy areas, indications, stages, MoA, RoA, molecule type and the key players in the development pipeline.

GlobalData’s report assesses the drugs in the Alpha Synuclein pipeline by therapy areas, indications, stages, MoA, RoA, molecule type and the key players in the development pipeline.

1:1,000); (2) cleaved caspase-3, as a neuronal apoptosis indicator (Cell signalling, 1:400); and (3) Ras GTPase-activating protein-binding protein 1 (G3BP1), as an SGs marker (Proteintech, 1:400). The ...

and activation of the caspase 3-mediated apoptotic pathway. Treatment with IB-DNQ alone or together with SOD1 inhibition effectively suppressed tumor growth, metastasis, and tumor-initiating potential ...

STAT5b knockdown in T84 CEC increased TNFα-dependent NF-κB and caspase-3 activation. GH inhibition of TNFα signalling was prevented by STAT5b knockdown. Conclusion: STAT5b maintains colonic barrier ...

Pine pollen is a yellow, powdery substance found in pine cones of certain pine tree species. Little is known about pine pollen nutritional value, and studies supporting any health claims are limited.