Scientists have identified a promising new target for cancer treatment by activating a DNA repair enzyme called TDP1, ...

The breakthrough research was conducted by scientists at the Indian Association for the Cultivation of Science (IACS), ...

In a promising development for cancer treatment, researchers have pinpointed a new target by activating a DNA repair enzyme known as Tyrosyl-DNA phosphodiesterase 1 (TDP1).

A centromere is a specialized location in the DNA that functions as the control center of cell division and is maintained, ...

Nek2a and Cdk1/2-cyclin A2 phosphorylate the cohesin subunit Pds5b, which is dephosphorylated by pericentromeric Sgo1-PP2A. Phosphorylated Pds5b ejects the cohesion protector sororin and recruits Wapl ...

A cascade of events"We closed a gap in our knowledge that was open for 10 years," says Duccio Conti, a postdoc in the Musacchio group and first author ...

[5] When bound to its cyclin partners, Cdk1 phosphorylation leads to cell cycle progression. Cdk1 activity is best understood in S. cerevisiae, so Cdk1 S. cerevisiae activity is described here. Cln1,2 ...