Matthew P. Strout, PhD, Michael A. Caligiuri, MD, and Clara D. Bloomfield, MD ...

We identified a novel 291 kb chromosomal inversion involving chromosome 3p in affected family members. This inversion disrupts the VHL gene between exon 2 and exon 3 and is thereby responsible for the ...

bDepartment of Applied Science at the Swiss Federal Institute of Technology, Zurich, Switzerland Treatment options for patients with chronic myeloid leukaemia (CML) and other types of leukaemia ...

or whether in fact the underlying rate of chromosome losses, gains and rearrangements is elevated in cells that are evolving towards cancer. The latter idea would be consistent with the hypothesis ...

Their findings, published in Cell, explain how chromosomes in some tumors undergo massive rearrangements and could lead to new strategies to avoid cancer drug resistance. Chromosome rearrangements ...

Microarray analysis identifies more chromosome abnormalities than traditional ... Currently, microarrays will not detect balanced rearrangements, but when combined with certain sequencing ...

Prior methods for making HACs have been limited by the fact that the DNA constructs used to make them tend to join together-;"multimerize"-;in unpredictably long series and with unpredictable ...

The parent carries a rearrangement of genetic material between chromosome 21 and another chromosome. This rearrangement is called a balanced translocation. No genetic material is gained or lost in a ...

Finally, single-chromosome immunofluorescence and Hi-C data suggest that mitotic chromosomes shrink during embryogenesis through decreased recruitment of condensin I, resulting in major rearrangements ...

This manuscript by Chang et al. reports the evolutionary patterns of Y-chromosome evolution in Drosophila, providing perhaps the most comprehensive interspecific comparison of Y chromosomes available ...