Zhijian “James” Chen received this year’s Albert Lasker Award for discovering cGAS, an enzyme which scopes out DNA-based ...

Physician Andrea Ablasser from the École polytechnique fédérale de Lausanne, virologist Glen Barber from Ohio State ...

Composition and methods patent granted claims covering compounds for treating broad range of inflammatory and autoimmune diseases and built on foundational intellectual property for the discovery of ...

It is extremely dangerous when, in response to either viral intruders or damage within the cell itself ... provide the following overall picture: The enzyme cGAS acts as a sensor for DNA in the ...

suggesting a pivotal role for the cGAS-STING pathway in the response of HNSCC. Previous studies have found that STING enhances cell death in HNSCC by regulating reactive oxygen species and DNA damage ...

MAIA Biotechnology, Inc., ("MAIA", the "Company"), a clinical-stage biopharmaceutical company developing targeted immunotherapies for cancer, today announces favorable interim survival benefit from ...

DNA damage responses, and selective cancer cell death. THIO-damaged telomeric fragments accumulate in cytosolic micronuclei and activates both innate (cGAS/STING) and adaptive (T-cell) immune ...

This useful study unveils that OGT deficiency triggers a DNA damage response that can affect immune status in colorectal cancers. It provides convincing evidence showing that OGT-mediated processing ...

Semi-quantitative PCR was conducted to evaluate mitochondrial DNA common deletion (CD ... oxidative damage to mtDNA. As mtDNA damage might lead to the accumulation of cytosolic mtDNA and triggering of ...

Intracellularly, cfDNA originating from apoptotic cells or intracellular pathogens can be sensed by AIM2 and cGAS-STING ... DAMP damage-associated molecular pattern, PAMP pathogen-associated molecular ...