Study reveals widespread dysregulation of transposable elements (TEs) in aging human brains with Alzheimer's disease, using ...

Epigenetics, the study of changes in gene function that do not involve alterations to the DNA sequence, plays a pivotal role ...

A research team, delving into the impact of excessive prenatal prednisone exposure (PPE) on fetal development, discovered ...

Studies have shown that epigenetic therapies can reprogram histone modifications in DMG tumor cells ... revealing that these drugs effectively inhibit tumor cell growth by increasing H3K27 acetylation ...

Studies have shown that epigenetic therapies can reprogram histone modifications in DMG ... inhibit tumor cell growth by increasing H3K27 acetylation (H3K27ac) and decreasing H3K27 trimethylation ...

Aberrant epigenetic modifications mediated by changes in DNA and histone methylation and acetylation patterns, in addition to non-coding RNAs, can disrupt normal cellular function and lead to ...

Core histones, the fundamental units of chromatin structure, are subject to many types of post-translational modifications such as acetylation ... focused on transcriptional coregulators, including ...

Notably, in the sepsis patients, TLR4-TIR acetylation was predominantly observed in CD16+ monocytes combined with elevated expression of M1 macrophage markers. In addition, the TIR domain complex was ...

At least 18 different forms of histone modification have been identified, most commonly at lysine (K) residues on histones H3 and H4 (Zhao and Garcia, 2015). Among these, acetylation, methylation, and ...