San Francisco 49ers wide receiver Deebo Samuel Sr. (calf) is expected to play in Sunday's showdown with the Patriots. Although the wideout was expected to be out longer, it appears he is ready to roll ...

The latest updates on George Kittle’s injury status for Week 4 vs. the New England Patriots. Stay informed with our ...

San Francisco 49ers wide receiver Deebo Samuel is expected to play Sunday against the New England Patriots, a source told ...

Here are five keys the 49ers (1-2) must accomplish to avoid losing a third straight game Sunday when they host the New ...

The San Francisco 49ers had a positive sign on Thursday. George Kittle, Brock Purdy, Deebo Samuel and Trent Williams all took part in practice. For Kittle, it was the second straight day he was on the ...

The San Francisco 49ers face the New England Patriots at 1:05 p.m. PDT on Sunday, Sept. 29 at Levi’s Stadium in Santa Clara, ...

Do the San Francisco 49ers bounce back in Week 4? After a tough loss as road favorites to the Los Angeles Rams in Week 3, the 49ers are the biggest favorite on ...

The San Francisco fans didn't get to see their influential tight end against the Los Angeles Rams in Week 3, but hopes have ...

The New England Patriots will look to avoid a third straight loss, following a 24-3 defeat at the hands of the New York Jets ...

SportsLine's model simulated New England Patriots vs. San Francisco 49ers 10,000 times and made its Week 4 NFL picks, ...