CDK2 inhibitors have received some attention at the 2024 ESMO Congress, with one candidate, PF-07104091, showing combination potential with CDK4-selective blockade in HR–positive, HER2–negative breast ...

(C) According to the classical model of cell cycle control, D-type cyclins and CDK4 or CDK6 regulate events in early G1 phase (not shown), cyclin E-CDK2 triggers S phase, cyclin A-CDK2 and cyclin ...

how the cell cycle machinery is employed to amplify centrioles is unclear. We use transgenic mice and primary airway epithelial cell culture to show that Cdk2, the kinase responsible for the G1 to S ...

Promising phase I and II trial data have emerged for these agents offering the potential to manipulate cell-cycle regulators to promote growth arrest, differentiation, or apoptosis. Flavopiridol ...

A centromere is a specialized location in the DNA that functions as the control center of cell division and is maintained, ...

Details of the presentation are listed below: About Cyclacel Pharmaceuticals, Inc.

To evaluate if PKC is involved in the mechanism of CAK activation, the phosphorylation of CAK and one CDK family member, cdk2, was monitored throughout the cell cycle. Results indicate that PKC ...

Calcineurin fine tunes the balance between proliferation and differentiation of Notch-responsive progenitors in the pancreatic ducts to enable beta cell regeneration in zebrafish.

A recent discovery has found a possible avenue to improve human health by better understanding how to engineer human stem ...

Detailed biophysical and computational studies on one such interaction reveal a marvelously intricate, temporally regulated, multistep conduit for signal transduction in the cell cycle.

Patients are preselected for CDKN2A and/or CDKN2B abnormalities -- Safety and efficacy data to be reported at an upcoming oncology medical ...

The Company believes that fadra’s inhibition of CDK2 and CDK9 may be superior to ... developing innovative cancer medicines based on cell cycle, transcriptional regulation and mitosis biology.