Mechanistically, the cleavage of TDP-43 at Asp89 by HIV-1 relies on Vpu-mediated activation of Caspase 3, and pharmacological inhibition of Caspase 3 activity effectively suppressed the HIV-1-induced ...

Their findings reveal the crucial role of macrophages and the protein caspase-11 in this context, hinting at promising therapeutic targets for RA and other periodontal infection-related diseases.

The researchers added yet one more piece to this puzzle using caspase-11-deficient mice. In these animals, inflammasome activation due to A. actinomycetemcomitans was suppressed. Most importantly ...

Periodontal disease, which affects the gums and tissues that surround the teeth, is one of the most prevalent dental conditions worldwide. Most often caused by the formation and accumulation of ...

These results revealed a new host defense mechanism mediated by apoptotic caspase activity. (A) Mitochondria were visualized by immunofluorescence using confocal microscopy. THP-1 PMA, Huh7 or A549 ...

GlobalData’s report assesses the drugs in the Caspase 2 pipeline by therapy areas, indications, stages, MoA, RoA, molecule type and the key players in the development pipeline.

The molecules developed by companies in Phase III, Phase I, Preclinical, and Discovery stages are 1, 1, 1, and 2 respectively. Caspase-2, also known as CASP2, is an enzyme involved in the activation ...

What is type 1 diabetes? In type 1 diabetes, the body can’t make insulin. Insulin is needed to help sugar (glucose) enter cells for energy. Without insulin, glucose builds up in the blood. This causes ...