Scientists have identified a promising new target for cancer treatment by activating a DNA repair enzyme called TDP1, ...

The breakthrough research was conducted by scientists at the Indian Association for the Cultivation of Science (IACS), ...

In a promising development for cancer treatment, researchers have pinpointed a new target by activating a DNA repair enzyme known as Tyrosyl-DNA phosphodiesterase 1 (TDP1).

A cascade of events"We closed a gap in our knowledge that was open for 10 years," says Duccio Conti, a postdoc in the Musacchio group and first author ...

A centromere is a specialized location in the DNA that functions as the control center of cell division and is maintained, ...

Figure 4-figure supplement 2. Five phosphorylation sites (Ser28, Thr31, Ser59, Ser76 and Thr480) in Slp1 identified in this study are indicated in red. Putative Cdk1 or MAPK phosphorylation sites in ...

The series of experiments are consistent with the idea that phosphorylation in the MELK TP region by CDK1 could affect the interactions between TP and the KA1 domain, hence affecting KA1 availability ...

Nek2a and Cdk1/2-cyclin A2 phosphorylate the cohesin subunit Pds5b, which is dephosphorylated by pericentromeric Sgo1-PP2A. Phosphorylated Pds5b ejects the cohesion protector sororin and recruits Wapl ...

GlobalData’s report assesses the drugs in the Cyclin Dependent Kinase 7 pipeline by therapy areas, indications, stages, MoA, RoA, molecule type and the key players in the development pipeline.