Study reveals widespread dysregulation of transposable elements (TEs) in aging human brains with Alzheimer's disease, using ...

Epigenetics, the study of changes in gene function that do not involve alterations to the DNA sequence, plays a pivotal role ...

Notably, in the sepsis patients, TLR4-TIR acetylation was predominantly observed in CD16+ monocytes combined with elevated expression of M1 macrophage markers. In addition, the TIR domain complex was ...

At least 18 different forms of histone modification have been identified, most commonly at lysine (K) residues on histones H3 and H4 (Zhao and Garcia, 2015). Among these, acetylation, methylation, and ...

The N-terminal tails of histones are subject to multiple post-translational modifications — including phosphorylation, ubiquitination, acetylation ... landscape of histone-methylation regulation ...

Histone acetylation is a dynamic process controlled by the antagonistic actions of two large families of enzymes — the histone acetyltransferases (HATs) and the histone deacetylases (HDACs).

GlobalData’s report assesses the drugs in the Double Homeobox Protein 4 pipeline by therapy areas, indications, stages, MoA, RoA, molecule type and the key players in the development pipeline.

Mechanistically, 8C reduced I/R injury by promoting histone acetylation which in turn activated the expression of antioxidant genes and inhibited cardiomyocyte (CM) apoptosis. Furthermore, we ...

of the illumination with a period of 400 min or longer reduces gene expression noise. We identified histone acetylation as being key to the large fluctuations (noise) in amplitude modulation (AM) ...