mstrust.org.uk3d
Simvastatin not effective at slowing disability progression in secondary progressive MS
Initial results from a phase III clinical trial show that simvastatin does not slow down progression in secondary progressive ...
Frontiers28d
Chromosomal instability as an architect of the cancer stemness landscape
Signaling pathways mediating the CSC response to CIN. CSC resistance to the stress caused by CIN occurs through preventing DNA damage or inactivating STAT1-mediated cell death (left panel), while ...
Frontiers1mon
High Interferon Signature Leads to Increased STAT1/3/5 Phosphorylation in PBMCs From SLE Patients by Single Cell Mass Cytometry
Most notably, IFN-H patients exhibit increased STAT1/3/5 phosphorylation downstream of cytokine stimulation and increased phosphorylation of non-canonical STAT proteins. These results suggest that IFN ...
eLife5y
PHLPP1 counter-regulates STAT1-mediated inflammatory signaling
Investigation of PHLPP1 function in macrophages reveals that it controls the magnitude and duration of inflammatory signaling by dephosphorylating the transcription factor STAT1 on Ser727 to inhibit ...