Interleukin 12 - Wikipedia
WEBInterleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, [1] macrophages, neutrophils, helper T cells and human B-lymphoblastoid cells in response to antigenic stimulation. IL-12 belongs to the family of interleukin-12.
Immunology of IL-12: An update on functional activities and ...
WEBDec 11, 2020 · One important group of cytokines are interleukins, in which the twelfth to be described in 1989 was Interleukin-12 (IL-12). In more than three decades, numerous papers have reported effects and functions of IL-12.
Interleukin-12: an update on its immunological activities, …
WEBInterleukin-12 (IL-12) is a heterodimeric cytokine composed of the p35 and p40 subunits. It is produced by antigen-presenting cells and plays a critical role in host defense against intracellular microbial infection and control of malignancy via its ability to stimulate both innate and adaptive immune effector cells.
Interleukin-12 and the regulation of innate resistance and …
WEBFeb 1, 2003 · Interleukin-12 (IL-12) is a heterodimeric pro-inflammatory cytokine that regulates T-cell and natural killer-cell responses, induces the production of interferon-γ (IFN-γ), favours the...
Immunology of IL-12: An update on functional activities and
WEBDec 11, 2020 · As its first identified member, Interleukin-12 (IL-12) named a whole family of cytokines. In response to pathogens, the heterodimeric protein, consisting of the two subunits p35 and p40, is secreted by phagocytic cells. Binding of IL-12 to the IL-12 receptor (IL-12R) on T and natural killer (NK) cel …
Interleukin-12: Functional activities and implications for disease
WEBInterleukin-12 (IL-12) was the first member of the IL-12 family of cytokines to be identified and has therefore become its eponym. It is a heterodimeric protein of two subunits (p35, p40) secreted by phagocytic cells in response to pathogens and mainly acts through STAT4 to induce IFN-γ production in T and NK cells.
IL-12 family cytokines: immunological playmakers - Nature
WEBJul 19, 2012 · The interleukin 12 (IL-12) family is unique in having the only heterodimeric cytokines, including IL-12, IL-23, IL-27 and IL-35. This feature endows these cytokines with a unique set of...
The Tale of IL-12 and IL-23: A Paradigm Shift
WEBFeb 1, 2019 · Interleukin-12 was considered to be the driving force behind pathological conditions associated with several autoimmune disease models, including experimental autoimmune encephalomyelitis (EAE) and collagen-induced arthritis, as well as models of ocular inflammation (1–4).
Interleukin - StatPearls - NCBI Bookshelf - National Center for ...
WEBAug 22, 2022 · Interleukin-12 (IL-12) Monocytes produce IL-12. Its principal targets are T cells. It causes induction of Th1 cells. Besides, it is a potent inducer of interferon gamma production by T lymphocytes and NK cells. Interleukin-13 (IL-13) CD4+T cells (Th2), NKT cells and mast cells synthesize IL-13.
IL-12 and IL-23 cytokines: from discovery to targeted ... - Nature
WEBJun 29, 2015 · The cytokine interleukin-12 (IL-12) was thought to have a central role in T cell–mediated responses in inflammation for more than a decade after it was first identified.