Nucleotide Metabolism - PMC - National Center for …
Overview of nucleotide metabolism. Nucleotides are key components of DNA and RNA (genetics), provide energy (ATP), and can activate signaling pathways.
Nucleotide Metabolism - an overview | ScienceDirect Topics
Nucleotide metabolism is a critical pathway that generates purine and pyrimidine molecules for DNA replication, RNA synthesis, and cellular bioenergetics. Increased nucleotide metabolism supports uncontrolled growth of tumors and is a hallmark of cancer.
Nucleotide metabolism: a pan-cancer metabolic dependency
Mar 27, 2023 · In this Review, we discuss recent studies that have generated mechanistic insights into the diverse biological roles of hyperactive cancer cell nucleotide metabolism.
Phospholipid biosynthesis modulates nucleotide metabolism and …
Jul 26, 2024 · Our findings highlight the critical role of phospholipid synthesis pathway choice in the integrative regulation of nucleotide metabolism, redox balance and membrane properties for cellular...
Nucleotide imbalance decouples cell growth from cell …
Aug 4, 2022 · Nucleotide metabolism supports RNA synthesis and DNA replication to enable cell growth and division. Nucleotide depletion can inhibit cell growth and proliferation, but how...
Regulation of mammalian nucleotide metabolism and biosynthesis
Feb 2, 2015 · Nucleotide synthesis is an energy intensive process that uses multiple metabolic pathways across different cell compartments and several sources of carbon and nitrogen. The processes are regulated at the transcription level by a set of master transcription factors but also at the enzyme level by allosteric regulation and feedback inhibition.
Lecture 32: Nucleotide Metabolism - MIT OpenCourseWare
Lecture 32: Nucleotide Metabolism. Description: Professor Vander Heiden introduces nucleic acid metabolism, then describes purine synthesis and uric acid, deoxyribonucleotides, pyrimidine synthesis, and the regulation of nucleic acid metabolism. Instructor: Prof. Matthew Vander Heiden.
Nucleotide Metabolism - SpringerLink
Jan 1, 2011 · Nucleotide metabolism occurs in all living organisms. The most prominent biomolecule, in terms of the number of reactions that it participates in, is the nucleotide, ATP. Although nucleotide metabolism is universal, it does differ to some extent in different...
Nucleotide Metabolism Behind Epigenetics - PMC - National …
Aug 30, 2021 · Here we review the crosstalk between gene expression, nucleotide metabolism, and cellular processes, and explore the role of metabolism in epigenetics as a critical regulator of biological events.
Nucleotide Metabolism - an overview | ScienceDirect Topics
Nucleotide metabolism is a common metabolic vulnerability of proliferating tumors. Metastasis formation depends on energy and antioxidant metabolism. Cancer cells impair the anti-tumor immune response.
- Some results have been removed