Aminopyrimidines: Recent synthetic procedures and anticancer activities
Jul 16, 2021 · Aminopyrimidine is a well-known heterocyclic motif containing a six-membered pyrimidine ring tethered with amino group where the 2-aminopyrimidine isomer is the most studied (Fig. 1).
2-Aminopyrimidine | C4H5N3 | CID 7978 - PubChem
2-Aminopyrimidine | C4H5N3 | CID 7978 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Research developments in the syntheses, anti-inflammatory …
Anti-inflammatory effects of pyrimidines are attributed to their inhibitory response versus the expression and activities of certain vital inflammatory mediators namely prostaglandin E 2, inducible nitric oxide synthase, tumor necrosis factor-α, nuclear factor κB, leukotrienes, and some interleukins. Literature studies reveal that a large ...
2‐Aminopyrimidines - Privileged Structures in Drug Discovery
This chapter discusses the applications of 2-aminopyrimidines in the treatment of cardiovascular, central nervous system, inflammatory, metabolic and oncology diseases.
Recent Advances in Pyrimidine-Based Drugs - PMC - National …
Jan 11, 2024 · This article surveys recent areas in which pyrimidines have had a major impact in drug discovery therapeutics, including anti-infectives, anticancer, immunology, immuno-oncology, neurological disorders, chronic pain, and diabetes mellitus.
Synthetic Strategies of Pyrimidine-Based Scaffolds as Aurora …
Aug 26, 2021 · Analysis of the structures of therapeutically active synthetic 2-aminopyrimidine derivatives indicated that the presence of aniline moiety, amide bond, and halogen atoms, along with heterocyclic substituents (piperazine, pyridine, imidazole), plays an important role in activity. 2-Aminopyrimidine is the most significant moiety accountable for ...
2-Aminopyrimidine: a privileged scaffold in kinase drug discovery
Jan 1, 2023 · 2-Anilinopyrimidine (2-AP) represents one of the most prevalent privileged scaffolds as a hinge-binding element. It is attracting the interest of medicinal chemists for the discovery of more kinase drugs. About 19 2-AP–derived kinase inhibitors were approved as …
2-Aminopyrimidine 97 109-12-6 - MilliporeSigma
Aldrich-A78608; 2-Aminopyrimidine 0.97; CAS No.: 109-12-6; Synonyms: 2-Pyrimidinamine; Linear Formula: C4H5N3; Empirical Formula: C4H5N3; find related products, papers, technical documents, MSDS & more at Sigma-Aldrich.
New 2-aminopyrimidine derivatives and their antitrypanosomal …
Sep 11, 2020 · Novel 2-aminopyrimidine derivatives were prepared from acyclic starting materials, benzylidene acetones and ammonium thiocyanates, via 5 steps, including ring closure, aromatization, S-methylation, oxidation to methylsulfonyl compounds, and formation of guanidines with suitable amines.
2-Aminopyrimidine 97 109-12-6 - MilliporeSigma
Oct 3, 2024 · 2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure-activity relationship and mode of action studies.
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