The Cyclin-dependent kinase 1: more than a cell cycle regulator
WEBOct 28, 2023 · CDK1-mediated phosphorylation of Rab5B regulates the dynamics and the maturation of early endosomes, impacting the sorting and recycling of internalised membrane proteins.
Cyclin-dependent kinase 1 - Wikipedia
WEBIn addition to regulation by cyclins, Cdk1 is regulated by phosphorylation. A conserved tyrosine (Tyr15 in humans) leads to inhibition of Cdk1; this phosphorylation is thought to alter ATP orientation, preventing efficient kinase activity.
Targeting CDK1 in cancer: mechanisms and implications
WEBJun 13, 2023 · CDK1 activation plays a critical role in a wide range of cancer types; and CDK1 phosphorylation of its many substrates greatly influences their function in tumorigenesis.
A cyclin-dependent kinase-mediated phosphorylation switch of
WEBOct 9, 2023 · CDK1-Y15 regulation via feedback loops consisting of CDC25 phosphatase and Wee1-like protein kinase 1-A (WEE1A; greyed out) seems to be less important for switch-like mitotic phosphorylation...
Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation ...
WEBMay 3, 2018 · Cdk1 recognizes a consensus phosphorylation site that consists of (Ser/Thr-Pro-X-Lys/Arg), where X is any residue and a serine or threonine is the site of phosphorylation. Especially important for recognition is …
The Cyclin-dependent kinase 1: more than a cell cycle regulator
WEBNov 11, 2023 · CDK1-mediated phosphorylation of Rab5B regulates the dynamics and the maturation of early endosomes, impacting the sorting and recycling of internalised membrane proteins. Moreover, CDK1 phosphorylates EPN1, a key regulator of the endocytic processes [ 31 ].
Global Analysis of Cdk1 Substrate Phosphorylation Sites Provides …
WEBSep 25, 2009 · We combined specific chemical inhibition of Cdk1 with quantitative mass spectrometry to identify the positions of 547 phosphorylation sites on 308 Cdk1 substrates in vivo.
CDK1-PP2A-B55 interplay ensures cell cycle oscillation via Apc1 …
WEBMay 28, 2024 · During interphase, inactive CDK1 allows PP2A-B55 to dephosphorylate Apc1-300L, preventing Cdc20 binding. Entering mitosis, activated CDK1 phosphorylates Apc1-300L and subsequently displaces of Apc1-300L, enabling the APC/C-Cdc20 complex formation and Cyclin B destruction.
Quantitative kinase and phosphatase profiling reveal that CDK1 ...
WEBSep 8, 2020 · We believe that direct phosphorylation of PP2Ac at Thr 304 by CDK1–cyclin B complex provides an additional layer of temporal regulation to reduce PP2A-B55 activity upon CDK1–cyclin B activation at the G 2-M transition of cell cycle to promote mitotic entry.
Fine Tuning the Cell Cycle: Activation of the Cdk1 Inhibitory ...
WEBMar 3, 2009 · Proteolysis of cyclin B is the major known mechanism that turns off Cdk1 during mitotic exit. Here, we show that mitotic exit also activates pathways that catalyze inhibitory phosphorylation of Cdk1, a mechanism previously known to repress Cdk1 only during S and G2 phases of the cell cycle.