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Structural Elements Governing GABA-A Receptor Channel …
WEBFeb 3, 2017 · Inhibition in the brain depends on rapid opening and closing of GABA-A receptor (GABAR) channels. Therapeutic drugs such as benzodiazepines (BZDs), barbiturates and general anesthetics modulate GABAR currents by binding to distinct allosteric sites that are far from the agonist binding sites.
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Cryo-electron microscopy reveals informative details of GABA
WEBJun 23, 2019 · GABARs are the major receptors mediating rapid inhibitory neurotransmission in the central nervous system and members of the pentameric ligand-gated ion channel (pLGIC) gene superfamily. The α1β3γ2L recombinant GABAR was isolated from a stable cell line and reconstituted into a lipid bilayer.
GABA beyond the synapse: defining the subtype-specific
WEBUsing whole-cell voltage clamp and rapid drug application, we measured the GABAR-subtype-specific properties to convey either synaptic or extrasynaptic signalling in a range of physiological contexts. α4βδ GABARs are optimally tuned to submicromolar tonic GABA and transient surges of micromolar GABA concentrations. α5β2γ2l GABARs are ...
In vivo electroretinographic studies of the role of GABAC receptors …
WEBThis study investigated roles of GABAR, especially GABACR (GABA (A)-ρ), in retinal signaling in vivo by studying effects on the mouse electroretinogram (ERG) of genetic deletion of GABACR versus pharmacological blockade using receptor antagonists.