Hantzsch ester - Wikipedia
Hantzsch ester refers to an organic compound with the formula HN (MeC=C (CO 2 Et)) 2 CH 2 where Me = methyl (CH 3) and Et = ethyl (C 2 H 5). It is a light yellow solid. The compound is an example of a 1,4- dihydropyridine. It is named after Arthur Rudolf Hantzsch who described its synthesis in 1881.
Applications of Hantzsch Esters in Organocatalytic ... - MDPI
Feb 16, 2023 · Hantzsch esters (1,4-dihydropyridine dicarboxylates) have become, in this century, very versatile reagents for enantioselective organic transformations. They can act as hydride transfer agents to reduce, regioselectively, a variety of multiple bonds, e.g., C=C and C=N, under mild reaction conditions.
Hantzsch esters: an emerging versatile class of reagents in …
Jun 27, 2019 · Over the last few decades, Hantzsch esters have proven to be a useful class of electron donors and proton sources in photoredox catalyzed processes. Moreover, under photoredox catalytic conditions, alkyl-1,4-dihydropyridines can serve as versatile types of alkylation reagents via oxidative fragmentation mechanisms.
Hantzsch Ester - Organic Chemistry Portal
An efficient reductive cyclization of o -nitrocinnamoyl compounds was achieved by employing Hantzsch 1,4-dihydropyridine diethyl ester as a biomimetic reducing agent in the presence of catalytic palladium on carbon. This approach was successfully applied to the synthesis of substituted quinolines.
Learning from the Hantzsch synthesis - American Chemical Society
Nov 7, 2000 · Four Hantzsch esters: nifedipine, an antihypertensive drug used worldwide; a DHP developed to overcome multidrug resistance; SNAP 5089, a potential treatment for benign prostatic hyperplasia; a new Hantzsch ester with selective adenosine receptor binding activity.
Hantzsch esters: an emerging versatile class of reagents in
Aug 7, 2019 · Hantzsch esters were often previously used as reductants in thermal catalytic hydrogenation reactions. Over the last few decades, Hantzsch esters have proven to be a useful class of electron donors and proton sources in photoredox catalyzed processes.
First discovered in 1882 by Arthur Hantzsch Derivatives exhibit important pharmacological properties such as antihypertensive, antibiotic, antiinflammatory, and antifungal activity
Hantzsch esters: an emerging versatile class of reagents in …
Aug 7, 2019 · Hantzsch esters were often previously used as reductants in thermal catalytic hydrogenation reactions. Over the last few decades, Hantzsch esters have proven to be a useful class of electron donors and proton sources in photoredox catalyzed processes.
Catalyst‐free Hantzsch Ester‐mediated Organic Transformations …
Aug 29, 2022 · In this review, complete exploration of visible-light enabled hantzsch esters mediated organic transformations in absence of external photocatalyst was summarized.
(PDF) Hantzsch esters: an emerging versatile class of reagents in ...
Jun 27, 2019 · This minireview highlights the recent advances of the chemistry of Hantzsch esters in photoredox catalyzed organic synthesis, with particular emphasis put on the reaction mechanisms.
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