Omega-3 polyunsaturated fatty acids inhibit IL-11/STAT3 …
WEBAug 17, 2021 · The data revealed that n-3 PUFAs inhibited IL-11 production in hepatocytes and STAT3 phosphorylation. In addition, it was observed that limited phosphorylation of ERK1/2 and reduced Fra-1 expression were associated with the effect of n-3 PUFAs on IL-11 production. STAT3 signaling plays an essential role in acute liver injury (6,28).
STAT3 activation through IL-6/IL-11 in cancer-associated …
WEBIn loss-of-function and gain-of-function experiments, using genetically modified mice with collagen type VI (COLVI)-specific signal transducer and activator of transcription 3 (STAT3) targeting, we evaluated STAT3 signalling in fibroblasts …
Pharmacologic inhibition of IL11/STAT3 signaling increases MHC …
WEBJun 26, 2023 · IL11/STAT3 signaling downregulated MHC-I and CXCL9 by inhibiting IFNγ-induced STAT1 phosphorylation. IL11 mutein competitively inhibit IL11 to upregulate CXCL9 and MHC-I in tumor and attenuated tumor growth.
IL-11 induces differentiation of myeloid-derived suppressor …
WEBSep 1, 2015 · IL-11-gp130 signalling causes activation of the JAK/STAT3 pathway. IL-11 is highly upregulated in many types of cancers and one of the most important cytokines during tumourigenesis and...
Pharmacologic inhibition of IL11/STAT3 signaling increases MHC …
WEBJun 26, 2023 · Recent studies have discovered an emerging role of IL11 in various colitis-associated cancers, suggesting that IL11 mainly promotes tumor cell survival and proliferation in regulating tumorigenesis. Herein we aimed to reveal a novel function of IL-11 through STAT3 signaling in regulating tumor immune evasion.
Interleukin-11-expressing fibroblasts have a unique gene …
WEBApr 16, 2021 · IL-11 induces the activation of colonic fibroblasts and epithelial cells through phosphorylation of STAT3.
Structures of the interleukin 11 signalling complex reveal gp130 ...
WEBIL-11 Δ10/Mutein strongly inhibited IL-11 Δ10 mediated STAT3 activation (IC 50 = 850 ± 275 nM, Fig. 4B ...
Emerging roles for IL-11 in inflammatory diseases - ScienceDirect
WEBJan 1, 2022 · Interleukin-11 (IL-11) is a cytokine that has been strongly implicated in the pathogenesis of fibrotic diseases and solid malignancies. Elevated IL-11 expression is also associated with several non-malignant inflammatory diseases where its function remains less well-characterized.
Emerging roles for IL-11 signaling in cancer development and ...
WEBIL-11 acts as a potent growth factor for various hematopoietic progenitors, and the growth of tumors of the gastrointestinal mucosa is fueled by IL-11 [22], consistent with the …
Unraveling the complexity of STAT3 in cancer: molecular …
WEBJan 20, 2024 · STAT3 is a transcription factor involved in various cancer hallmarks and a promising therapeutic target. This review summarizes the regulation, functions and inhibitors of STAT3 in cancer, and proposes new strategies for …