An Overview of the Synthesis and Antimicrobial, Antiprotozoal, …
Jan 25, 2021 · Thiazole is an important scaffold in medicinal chemistry, easy to synthesize from a wide variety of starting compounds. To date, many organic compounds containing one or more thiazole rings, showing promising antimicrobial, antiprotozoal, and antitumor activities, have been added to the literature.
Thiazole Ring—A Biologically Active Scaffold - PMC
May 25, 2021 · Thiazole derivatives can be synthesized by the Robinson–Gabriel method based on the cyclization of acylaminocarbonyl compounds in the presence of stoichiometric amounts of phosphorus pentasulfide . An interesting synthesis of thiazole is mediated by reduction of 2-methylthiothiazole .
An Overview of the Synthesis and Antimicrobial, Antiprotozoal, …
Jan 25, 2021 · Thiazole and bisthiazole are heterocyclic compounds with diverse pharmacological activities, such as antibacterial, antifungal, antiprotozoal, and antitumor effects. This review covers the methods for the synthesis of these derivatives and their biological potential for drug discovery.
Isolation, biological activity and synthesis - ScienceDirect
Jan 15, 2024 · In 2016, the fungus Penicillium oxalicum collected from the Chinese grasshopper Acrida cinerea was found to contain penicilliumthiamine B (42) [55] (Scheme 6). This 1,2,4-thiadiazole natural product possesses anticancer properties (HGC-27; IC 50 172.3 μM) through inhibition of AKt/Protein Kinase B (PKB) (473).
Thiazoles: having diverse biological activities
Jun 28, 2011 · Thiazoles are heterocyclic compounds with various biological activities, such as antitumor and cytotoxic effects. The article reviews the design and development of different thiazole derivatives, including some with 4-bromo-2-formyl thiazole moiety.
Synthesis and Evaluation of Antimicrobial Activity of 1, 3, 4 ...
Mar 3, 2021 · Thiadiazoles is a bioisosteric replacement of Thiazole moiety. Also, it is a bioisostere of Oxadiazole, Oxazole and Benzene. Substitution of these heterocyclic systems with a Thiadiazole by and large leads to analogues with improved activity because sulfur atom imparts enhanced liposolubility.
Cytotoxic 1,3-Thiazole and 1,2,4-Thiadiazole Alkaloids from Penicillium …
Feb 26, 2016 · Two new thiazole and thiadiazole alkaloids, penicilliumthiamine A and B (2 and 3), were isolated from the culture broth of Penicillium oxalicum, a fungus found in Acrida cinerea. Their structures were elucidated mainly by spectroscopic analysis, total synthesis and X-ray crystallographic analysis.
Synthesis, characterization and antimicrobial studies of a few …
May 29, 2013 · The thiazole-diamides have been identified as highly potent γ-secretase inhibitors (Yuhpyng et al., 2007). According to the literature, thiazole derivatives could be potent antimicrobials such as antifungal and antibacterial.
Overview on Biological Activities of Thiazole Derivatives
Mar 8, 2022 · Thiazole derivatives exhibit a great antifungal activity with low cytotoxicity to the human cells . Bis-Thiazole derivatives have been synthesised and evaluated for antifungal activity against Aspergillus niger, Aspergillus flavus, Penicillium chrysogenum and Fusarium moniliforme .
Review of the synthesis and biological activity of thiazoles
It was found that the insertion of thiazole fragment into a bis-thiourea derivatives made it more active against A549 (human lung adenocarcinoma) and C6 (rat glioma) cell lines. [ 53 ] …
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