Crosstalk between Plk1, p53, cell cycle, and G2/M DNA damage
WEBDec 9, 2021 · While the induction of DNA damage in Plk1-depleted p53-wt cancer cells can be countered with activation of the p53 pathway, Plk1 depletion can induce cell cycle arrest of p53-null cancer...
Polo-like kinase 1 (Plk1) inhibits p53 function by physical ... - PubMed
WEBJun 11, 2004 · In addition to its cell cycle-regulatory function, Plk1 has a potential role in tumorigenesis. Here we found for the first time that Plk1 physically binds to the tumor suppressor p53 in mammalian cultured cells, and inhibits its transactivation activity as well as its pro-apoptotic function.
Present and Future Perspective on PLK1 Inhibition in Cancer …
WEBJun 2, 2022 · In this review, we will summarize the evidence suggesting the role of PLK1 in response to DNA damage, including DNA repair, cell cycle progression, epithelial to mesenchymal transition, cell death pathways and cancer-related immunity.
The responses of cancer cells to PLK1 inhibitors reveal a novel ...
WEBNov 23, 2017 · PLK1 inhibition is a promising therapeutic strategy and works by arresting cells in mitosis due to monopolar spindles. The p53 tumour suppressor protein is a short-lived transcription...
PLK1 induces chromosomal instability and overrides cell cycle ...
WEBMar 1, 2021 · We investigated whether increased Plk1 expression modulates p53 signaling in Plk1 PMEFs. We first analyzed p53 levels and activity (phospho-p53 [Ser15]) by Western blot in WT and Plk1 PMEFs synchronized in G 2 (when PLK1 expression is high ( 1 )).
WEBIt has been demonstrated that both Plk1 and p53 interactions play a critical role in regulating the DNA damage checkpoint5. Remarkably, Liu and co-workers5 have shown that depletion of Plk1...
Polo-like kinase 1 (PLK1) signaling in cancer and beyond
WEBNov 1, 2021 · Complex interplay between PLK1 and p53 ensures timely PLK1 activation when DNA damage is repaired, allowing cell cycle progression, whereas when DNA is severely damaged, p53 transcriptionally inhibits PLK1 and …
PLK1, A Potential Target for Cancer Therapy - PMC - National …
WEBNov 24, 2016 · In this article, we examined PLK1’s structural characteristics, its regulatory roles in cell mitosis, PLK1 expression, and its association with survival prognoses of cancer patients in a wide variety of cancer types, PLK1 interaction networks, and PLK1 inhibitors under investigation.
PLK1 promotes the mitotic surveillance pathway by controlling …
WEBOct 27, 2023 · PLK1 inhibition not only confines 53BP1 to KTs but also prevents its association with p53 in the mitotic cytosol. Furthermore, PLK1 activity in cells experiencing a single prolonged prometaphase appears to be …
Crosstalk between Plk1, p53, cell cycle, and G2/M DNA damage …
WEBDec 9, 2021 · To study crosstalk between Plk1, p53, and G2/M DNA damage checkpoint leading to differential cell cycle regulations, we developed a computational model by extending our recently developed model of mitotic …