STAT1 - Wikipedia
WEBSignal transducer and activator of transcription 1 (STAT1) is a transcription factor which in humans is encoded by the STAT1 gene. It is a member of the STAT protein family. [5]
STAT1 Gene - GeneCards | STAT1 Protein | STAT1 Antibody
WEBAug 6, 2024 · Complete information for STAT1 gene (Protein Coding), Signal Transducer And Activator Of Transcription 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium.
The JAK/STAT signaling pathway: from bench to clinic
WEBNov 26, 2021 · The signal transduction and activator of transcription (STAT) family have six members: STAT1 (STAT1 has two splicing isoforms, STAT1α and STAT1β), STAT2, STAT3 (STAT3 has two splicing isoforms ...
STAT1 and Its Crucial Role in the Control of Viral Infections
WEBApr 7, 2022 · STAT1 is the major mediator of the cellular response to interferons (IFNs) [4,5]. It plays a key role in the immune response against viruses and mycobacteria by transducing in the nucleus the signal from type I IFNs (IFNα, IFNβ, IFNε, IFNκ, and IFNω), type II IFN (IFNγ) and type III IFN (IFNλ).
STAT1 signal transducer and activator of transcription 1 [ (human)]
WEBSTAT1 mediated downregulation of the tumor suppressor gene PDCD4, is driven by the atypical cadherin FAT1, in glioblastoma. USP39 Promotes the Viability and Migration of Head and Neck Squamous Cell Carcinoma Cell by Regulating STAT1.
The JAK/STAT signaling pathway: from bench to clinic
WEBNov 26, 2021 · In this review, we discussed the composition and function of the JAK/STAT pathway and discussed the role of JAK/STAT in various diseases. Dysregulation of the JAK/STAT signaling pathway is recognized as a major contributor to various diseases, especially malignant tumors, and autoimmune diseases.
STAT1 and Its Crucial Role in the Control of Viral Infections
WEBApr 7, 2022 · STAT1 plays a key role in the immunoglobulin class-switch recombination through the upregulation of T-bet; it also plays a key role in the production of T-bet+ memory B cells that contribute to tissue-resident humoral memory by mounting an IgG response during re-infection.
Complex roles of Stat1 in regulating gene expression
WEBMay 25, 2000 · Stat1 is a fascinating and complex protein with multiple, yet contrasting transcriptional functions. Upon activation, it drives the expression of many genes but also suppresses the transcription...
Regulation of the linear ubiquitination of STAT1 controls antiviral ...
WEBMar 2, 2020 · Here, we show that STAT1 has linear ubiquitination at Lys511 and Lys652 residues in intact cells, which inhibits STAT1 binding to the type-I interferon receptor IFNAR2, thereby restricting...
Complex roles of Stat1 in regulating gene expression - PubMed
WEBMay 15, 2000 · Stat1 is a fascinating and complex protein with multiple, yet contrasting transcriptional functions. Upon activation, it drives the expression of many genes but also suppresses the transcription of others.